In October 2024, Andreessen donated $2.5 million to the pro-Trump Right for America PAC.

Andreessen is co-founder of venture capital firm Andreessen Horowitz which is heavily invested in crypto currency, artificial intelligence startups and financial technology firms. Andreessen been heavily involved in shaping the Trump administration and DOGE and said in December 2024 that he was spending “half” his time at Mar-a-Lago to advise Trump on tech and economic policy for his second term

In a private WhatsApp group chat with Trump administration officials and other people in the tech industry, Andreessen attacked immigration and diversity, equity and inclusion (DEI) policies on college campuses as “systematically cut[ting] most of the children of the Trump voter base out of […] higher education and corporate America.” Andreessen said universities would “pay the price” for DEI.